Comparison of pH values for four different buffer solutions of TAPSO at 25 and 37°C

CHED 294

Daniel A. Kaufmann, dkaufmann@drury.edu, Chandra N. Roy, croy@drury.edu, Nicholas W. Grove, ngrove@drury.edu, Lakshmi N. Roy, lroy@drury.edu, and Rabindra N. Roy, rroy@drury.edu. Walter H. Hoffman Department of Chemistry, Drury University, 900 N. Benton Ave., Springfield, MO 65802
The control of acidity in the physiological pH range 6 to 8 is of importance in the biomedical field. The buffer compound TAPSO has been studied. Conventional paH values for four physiological buffer solutions have been studied: (i) 0.05 molal TAPSO + 0.05 molal sodium TAPSOate; (ii) 0.05 molal TAPSO + 0.05 molal NaTAPSOate + 0.11 molal NaCl; (iii) 0.08 molal TAPSO + 0.08 molal NaTAPSOate; and (iv) 0.08 molal TAPSO + 0.08 molal NaTAPSOate + 0.08 molal NaCl; at temperatures 25 and 37°C and have been assigned based on Pitzer's theory and Bates-Guggenheim convention. The results are useful in clinical studies.