Synthesis of potential muscarinic agents for alzheimer's application

CHED 497

Andrea Ovierto, jboulos@mail.barry.edu, Yaneirys Cruz, cruzy@bucmail.barry.edu, John Boulos, jboulos@mail.barry.edu, Adauri Soprani, soprania@bucmail.barry.edu, and Christopher Akel. Department of Chemistry, Barry University, 11300 NE 2nd Ave., Miami Shores, FL 33161
A series of piperidinium hydrochloride and methyl iodide salts were synthesized and tested for muscarinic activity. These compounds are intended as M1 muscarinic agonists to mimic the effects of acetylcholine on post-synaptic cells. M1 selective agonists have been shown to be of therapeutic value for the treatment of Alzheimer's disease.
 

Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008