Synthesis of 9-(methylsulfoxide)anthracene in the investigation of photoinduced DNA cleavage

CHED 474

Cristina Sacco, cs2688@ship.edu and Allison H. Predecki, ahpred@ship.edu. Department of Chemistry, Shippensburg University, 1871 Old Main Drive, Shippensburg, PA 17257
Aryl sulfoxides are known to undergo photoinduced radical DNA cleavage. Synthesis of 9-(methylsulfoxide)anthracene has been accomplished in two steps, beginning with 9-bromoanthracene. DNA cleavage studies with this specific aryl sulfoxide will be discussed along with investigations into binding effects and cleavage mechanism.
 

Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008