Guest-host chemistry of p-sulfonatocalix[6]arene with guanadinium containing guests

CHED 985

Shehan L. Don Talagala, sldontal@colby.edu, Thomas W. Shattuck, twshattu@colby.edu, Peter D. Foster, and Cassandra L. Newell, clnewell@colby.edu. Department of Chemistry, Colby College, 7272 Mayflower Hill, Waterville, ME 04901
The main objective of our work is to investigate the guest-host binding interactions of p-sulfonatocalix[6]arene in aqueous media. The guests contain guanadinium and amine functional groups. The goal is to use these findings to predict guest-host interactions, which would enable us to design effective guest-host pairs. We used two guests that had different rigidities with respect to rotational freedom. We used Isothermal Titration Calorimetry, to titrate the basic amine guests in to the host. We ran the titrations at different pHs to determine the effects of charge, and conformational changes caused by speciation.