CHED 678 |
| Linear co-polymers composed of N-isopropylacrylamide with low concentrations of N,N'-cystaminebisacrylamide (p(NIPAm-co-CBAm)) undergo a reversible, thermoresponsive phase transition. Over a range of 2–3 °C near 32 °C, these polymers change from hydrophilic to hydrophobic chains. The temperature-dependent adsorption of bovine serum albumin (BSA) onto p(NIPAm-co-CBAm)-coated gold surfaces is investigated. P(NIPAm-co-CBAm) chains were synthesized with 0.00% and 0.20% CBAm by mass relative to NIPAm. A quartz crystal microbalance was used to measure BSA adsorption onto a gold surface in the presence and absence of polymer at 25 °C and 40 °C. On clean gold, there was a drop in frequency ranging from 80–200 Hz after the addition of BSA at 25 °C and 40–100 Hz at 40°C, indicating less protein adsorbed at higher temperature. The frequency change, 10–60 Hz, in the presence of 0.20% CBAm at 25 °C indicated less protein adsorption with polymer present. |
|
Undergraduate Research Poster Session: Polymer Chemistry
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |