Biomolecular sensing using Brewster's angle straddle reflective interferometry

CHED 281

Benjamin W. Martin, bmartin3@mail.rochester.edu and Lewis J. Rothberg, rothberg@chem.rochester.edu. Department of Chemistry, University of Rochester, 2051 Michigan Ave, Lima, NY 14485
Brewster's Angle Straddle Reflective Interferometry (BAS-RI) has many applications to biomolecular sensing and screening. BAS-RI can be used to screen and study the interactions of large libraries of molecules with an unlabeled biomolecule of interest with high throughput. We have used the method to study promotion and inhibition of amyloid plaque aggregation by small molecules.