Synthesis and characterization of a new series of 5-formyl-2-furan-sulfonic acid thiosemicarbazone compounds

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Erik P. Hoy, ephoy21@tntech.edu, Erica Stoner, elstoner21@tntech.edu, Rachel C. Huxford, rchuxford21@tntech.edu, and Edward C. Lisic, edlisic@tntech.edu. Department of Chemistry, Tennessee Technological University, Box 5055, Cookeville, TN 38505
This work will present the synthesis of a new series of 5-formyl-2-furan sulfonic acid thiosemicarbazone compounds. A series of thiosemicarbazides and semicarbazides(4-methylthiosemicarbazide, 4-ethyl-3-thiosemicarbazide, 4-phenyl-3-thiosemicarbazide, 4-benzyl-3-thiosemicarbazide, thiosemicarbazide, 4-phenylthiosemicarbazide hydrochloride, 4,4-bimethyl-3-thiosemicarbazide, and semicarbazide hydrochloride) were combined with 5-formyl-2-furan sulfonic acid sodium salt to synthesize a new series of eight compounds. The new compounds were characterized via 1H NMR. We postulate that the new compounds exhibit a weak hydrogen-bonded hydrazinic proton to form a ring.