CHED 441 |
| Recently, our lab has developed a one-pot synthesis for the reductive alkylation of malononitrile to efficiently prepare monosubstituted malononitriles. Once a monosubstituted derivative has been formed, simple alkylation techniques can be used to create new derivatives. When the monosubstituted derivative contains a pyridyl or phenol substituent (from 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, vanillin, 3-pyridinecarboxaldehyde, 3-pyridinecarboxaldehyde) alkylation is selective and disubstituted malononitriles are obtained. Reaction of the disubstituted malononitriles finally allows for pyridyl or phenol alkylation. Analogous disubstituted malononitrile derivatives have been found to be useful intermediates and/or targets for creation of numerous agricultural pesticides and pharmaceutical chemicals.
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Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |
