CHED 820 |
| During cell division a multi-subunit protein complex holds replicated chromosomes together. This complex, known as the cohesin complex, is essential for cell proliferation and ensures the proper segregation of replicated chromosomes. α-kleisin proteins are vital components of the cohesin complex in both meiosis and mitosis. There are four α-kleisin proteins in Arabidopsis thaliana. AtSYN1, a REC8 ortholog, functions in the meiotic complex, while AtSYN2 and AtSYN4, SCC1 orthologs, represent the mitotic cohesins. Previous analysis of AtSYN3 has shown that it localizes primarily in the nucleolus and a T-DNA knockout mutation causes female gametophyte lethality suggesting that AtSYN3 may not function as a typical cohesin. Utilizing RNA interference this possibility was tested further. Results show similar phenotypes to that of the knockout mutation, reinforcing the hypothesis that AtSYN3 may have evolved a specialized role in controlling rDNA. |
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Undergraduate Research Poster Session: Biochemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |