CHED 793 |
| Anthracycline derivatives such as Daunorubicin are known chemotherapeutic agents. A novel napthaquionone adduct named TU100 (N-methyl-5H-benzocyclohepthanaphthalene-5,12-imine) was recently synthesized that has a similar skeleton structure as an anthracycline. We recently sent TU 100 to the National Cancer Institute who examined its effects on tumor cell lines. The NCI's preliminary results suggest that TU 100 may be a cancer killing agent. The goal of this project was to develop a cell viability assay to determine how TU100 kills cancer cells. Preliminary results indicate it effectively kills cancer cells at concentrations similar to known chemotherapeutic agents. Efforts are now ongoing to determine if TU100 induces apoptosis by examining expression of apoptotic molecular markers such as caspases, heat shock proteins, and DNA cleavage. Future efforts will be directed towards identifying the molecular target(s) of TU100 and enhancing its effectiveness via chemical modification. |
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Undergraduate Research Poster Session: Biochemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |