Synthesis and biological evaluation of 3-alkylaryl-3-arylmethoxytropane derivatives at serotonin transporters

CHED 1318

Monte E Dipalma, mtrudell@uno.edu1, Sari Izenwasser2, and Mark L. Trudell, mtrudell@uno.edu1. (1) Department of Chemistry, University of New Orleans, New Orleans, LA 70148, (2) Department of Psychiarty and Behavioral Sciences, University of Miami School of Medicine, 1695 NW 9th Avenue, Suite 3302 (D21), Miami, FL 33136
A series of 3-alklyaryl-3-arylmethoxytropane derivatives has been synthesized and evaluated for potency at serotonin transporters (SERT) in rat brain tissue preparations. The synthesis, serotonin transporter affinity and structure-activity relationships of these novel compounds will be presented.
 

Undergraduate Research Poster Session: Medicinal Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008