Broad-spectrum antibacterial activities of clay minerals


Shelley Haydel, Biodesign Institute: Center for Infectious Diseases & Vaccinology, Arizona State University, Box 875401, Tempe, AZ 85287-5401 and Lynda Williams,, School of Earth and Space Exploration, Arizona State University, Box 871404, Tempe, AZ 85287-1404.

Geological nanomaterials have been used to heal skin infections since the earliest recorded history, and specific clay minerals may prove valuable in the treatment of bacterial diseases, including infections for which there are no effective antibiotics. We have previously shown that a specific iron-rich clay mineral has antibacterial activity against several Gram-negative, Gram-positive, and mycobacterial pathogens. We have continued to investigate the antimicrobial properties of clay minerals and have subjected more than 20 clay minerals to broth culture susceptibility testing of antibiotic-sensitive and antibiotic-resistant pathogenic bacteria to assess the feasibility of using clay minerals as therapeutic agents. Two specific minerals demonstrated bactericidal activity against pathogenic Escherichia coli, antibiotic-resistant E. coli, Salmonella enterica serovar Typhimurium, Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA). Ongoing research is aimed at investigating the mechanism of action of these antibacterial minerals and understanding how these clays promote bactericidal and bacteriostatic effects.


Clay Minerals and Health
1:30 PM-5:10 PM, Sunday, April 6, 2008 Morial Convention Center -- Rm. 213, Oral

Division of Geochemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008