EPR studies of erythrocyte membrane of hypertensive and normotensive rats: Effects of antioxidants

CHED 1295

Derick Dalhouse, dalhouse@mnstate.edu1, Joelle Rolfs, rolfsjo@mnstate.edu2, Abbas Pezeshk, pezeshk@mhd1.moorhead.msus.edu3, Maria Floer, floerma@mnstate.edu2, and Kristoffer Brandvold, kristofferbrandvold@hotmail.com2. (1) Department of Psychology, Minnesota State University Moorhead, Moorhead, MN 56563, (2) Department of Chemistry, Minnesota State University Moorhead, Moorhead, MN 56563, (3) Department of Chemistry, Moorhead State University, Moorhead, MN 56563
Systemic hypertension is a complex disease state resulting in chronically elevated arterial blood pressure. Differences in the membrane fluidity of erythrocytes were observed in spontaneously hypertensive rats (SHR) and Witar-Kyoto rats (WKY). Changes in the membrane fluidity and in blood pressure of both SHR and WKY rats were observed after treatment with the antioxidants probucol and vitamin E. Rats were injected with the antioxidants and weight and blood pressure data were maintained on them. Membrane fluidity was studied using EPR and spin labeling technique. Our preliminary data indicate that treatment with an antioxidant decreases both the blood pressure and increases membrane fluidity.
 

Undergraduate Research Poster Session: Medicinal Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008