Antibacterial natural products from Hypericum densiflorum

CHED 1283

Matthew S. Campbell, Ashlee A. Zelinsky, and Geneive E. Henry, henry@susqu.edu. Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, PA PA 17870
The Hypericum genus is a rich source of structurally diverse natural products which possess a wide range of biological activities. An acetone extract of the aerial parts of Hypericum densiflorum showed strong antibacterial activity against Staphylococcus aureus and Bacillus subtilis. The extract was purified by column chromatography to afford a triglyceride, terpenes, flavonoids and acylphloroglucinol derivatives. The structures were determined on the basis of NMR and MS data. Some of these compounds inhibited the growth of S. aureus and B. subtilis. The results of these studies will be presented.