CHED 486 |
| Suzuki couplings are powerful chemical reactions commonly employed in academic and industrial research settings to generate functionalized biaryls. We have developed a discovery-based lab for the organic chemistry undergraduate laboratory that explores green Suzuki coupling using water as a solvent, and exposes students to the professional responsibilities of a pharmaceutical researcher. Specifically, students take on the role of a medicinal chemist striving to identify the greenest and most cost-effective method out of three proposed synthetic approaches to make ethyl-4-phenylbenzoate, 1. Biaryl 1 demonstrates promise as a lead compound in the discovery of new non-steroidal anti-inflammatory drugs, and scale-up of this compound is necessary for future studies. In our work, the development and implementation of green aqueous Suzuki coupling experiments in a traditional introductory organic chemistry course is described.
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Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |
