Infrared and Raman spectra of adenine and its metal complexes

CHED 1177

Hadijatu Mumini, contehmumini79@yahoo.com1, Emanuel A. Waddell, ewaddell@chemistry.uah.edu2, Stephen Shreeves2, and Nsoki Phambu, nphambu@tnstate.edu3. (1) Chemistry, Tennessee State University, 3500 John A Merritt Blvd, Nashville, TN 37209, (2) Chemistry, University of Alabama in Huntsville, MSB 203C, John Wright Drive, Huntsville, AL 35899, (3) Department of Chemistry, Tennessee State University, 3500 John A Merritt Blvd, Nashville, TN 37209
Adenine is a constituent of nucleic acids and as such, adenine-metal ion interactions bear significant biochemical importance. This study was designed to examine the interaction of adenine with arsenic, copper, mercury, and zinc ions. The study was carried out at different pH values and metal ion/ligand concentrations using infrared and Raman techniques. Infrared and Raman spectra have shown some marker bands useful to identify the sites involved in metal chelation at a specific pH value. Particularly the preferred binding sites on adenine are two N atoms of the adenine ligand for Cu, Hg and Zn, and only N atom of the amino group for As. Raman spectra clearly show the metal-adenine vibration in the low frequency region. The stability constants calculated using electronic spectra demonstrated that the complexes of Cu and Hg with adenine are the most stable. Structural changes were also characterized by 1H NMR and potentiometric titration techniques
 

Undergraduate Research Poster Session: Inorganic Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008