CHED 379 |
| We designed a microscale synthesis of a bisalkylated L-Alanine derivative. The synthesis, characterization, and chiroptical properties of the L-alanine derivative will be reported. We used the exciton chirality method to assign absolute configuration of the derivative. Two quinolines were used to alkylate L-Alanine followed by complexation with Cu(II) to create a conformationally rigid, asymmetric product. This species featured a right-handed helical conformation of the chromophores and a negative couplet in circular dichroism indicating an S-configuration. This procedure teaches students at Doane College classic organic synthesis, purifications, and characterization methods, but most importantly, they learn how the absolute configuration of a chiral amine is related to chiroptical spectroscopy. |
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Undergraduate Research Poster Session: Chemical Education
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |