The use of equilibrium dialysis to determine the partition ratios between intravenous lipid suspensions and chemical agents in different environments

CHED 1325

Clinton J. Borchardt, C08Clinton.Borchardt@usafa.edu1, John S. Wilkes, john.wilkes@usafa.edu1, Joseph A. Levisky, Joseph.Levisky@usafa.af.mil1, Cynthia A. Corley, Cynthia.Corley@usafa.edu1, Ralph Hutchinson2, and Dan J. Kopacz3. (1) Department of Chemistry, US Air Force Academy, 2355 Fairchild Dr, USAF Academy, CO 80840, (2) Department of Chemistry, United States Air Force Academy, 2355 Fairchild Dr Suite 2N225, Colorado Springs, CO 80841, (3) Anesthiology, Surgical Center at Premier, 3920 N Union Blvd., Colorado Springs, CO 80907
Intravenous lipid suspensions have been used in medical situations to compensate for lack of caloric intake in those patients incapable of ingesting adequate amounts of fat substances. The same intravenous lipid suspensions have been demonstrated to be effective in reversing cardio-toxic events following inadvertent exposures to bupivicaine (Marcaine), a local anesthetic. In this report, we describe the results of our attempts to demonstrate that the lipid substances have the potential to sequester other chemical agents.
 

Undergraduate Research Poster Session: Medicinal Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008