Reactivity of the Re(CO)3+ core with monodentate aliphatic and aromatic amines and thioethers in aqueous solution

CHED 1218

Brenton R. Franklin, brfran08@holycross.edu1, Natalie V. Barone, nb18@uakron.edu2, Anil Cetin, ac30@uakron.edu2, Christopher J. Ziegler, ziegler@uakron.edu2, and Richard S. Herrick, rherrick@holycross.edu1. (1) Department of Chemistry, College of the Holy Cross, 1 College St, Worcester, MA 01610, (2) Department of Chemistry, University of Akron, Akron, OH 44325-3601
Due to synthetic similarities with technetium, we employed the Re(CO)3+ fragment with various simple, biologically relevant, monodentate ligands to determine its elementary reactivity in aqueous solutions using Re(CO)3(H2O)3+. [Re(CO)3L3]X, L = ammonia, pyridine, N-methyl imidazole and tetrahydrothiophene; X = Br-, PF6- compounds were facilely prepared and structurally characterized. Increasing ligand basicity produced dimeric compounds as the only products observed. Covalent, Re(CO)3L2Br, compounds were produced with these ligands in non-aqueous solvent. All ionic complexes synthesized were readily prepared with Re(CO)3(H2O)3+ and showed promise for this synthon as an appropriate reagent for aqueous production of technetium-based diagnostic imaging agents.
 

Undergraduate Research Poster Session: Inorganic Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008