Erythrocyte membrane studies of hypertensive and normotensive rats: Effects of 9-hydroxy xanthene

CHED 1296

Derick Dalhouse, dalhouse@mnstate.edu1, Abbas Pezeshk2, Maria Lindsay, M_Lindsays@hotmail.com3, Joelle Rolfs, rolfsjo@mnstate.edu2, and Kristoffer Brandvold, kristofferbrandvold@hotmail.com2. (1) Department of Psychology, Minnesota State University Moorhead, Moorhead, MN 56563, (2) Department of Chemistry, Minnesota State University Moorhead, Moorhead, MN 56563, (3) Department of Chemistry, Minnesota State University, Moorhead, 1117 42nd St SW, Apt 211, Fargo, ND 58103
Spontaneously hypertensive (SHR) rats and normotensive (WKY)rats were treated with 9-hydroxy xanthene to determine the effects of the drug on blood pressure, pulse, and cardiac and red blood cell membrane fluidity. The rats were treated three times per week with 200 mg/100 g body weight for four weeks and blood pressure, pulse, and body weight were collected once weekly. At the end of the study blood was collected via heart puncture in heparinized tubes for membrane fluidity analysis. Using spin label technique and EPR, the values of maximum splitting parameter for a fatty acid spin label (5-SASL) incorporated in erythrocyte membranes of both SHR and WKY rats were compared. The results of this study will be presented.
 

Undergraduate Research Poster Session: Medicinal Chemistry
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The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008