Imidazole-4,5-dicarboxylic acid libraries: Anilines and amino acid ester substituents

CHED 1303

Rachael Johnston, rachael-johnston@utulsa.edu1, John C. DiCesare, john-dicesare@utulsa.edu2, and Paul W. Baures, paul-baures@utulsa.edu2. (1) Department of Chemistry and Biochemistry, The University of Tulsa, Keplinger Hall, 800 South Tucker Drive, Tulsa, OK 74104, (2) Department of Chemistry and Biochemistry, University of Tulsa, Keplinger Hall, 800 South Tucker Drive, Tulsa, OK 74104
Molecular libraries were prepared from an imidazole-4,5-dicarboxylic acid scaffold by creating amides with anilines and amino acid ester combinations. A total of 9 anilines and 9 amino acid esters were used in order to give the 81 dissymmetrically disubstituted imidazole-4,5-dicarboxamides. Column chromatography on silica gel yielded pure products as determined by LC-MS analysis. The samples were submitted to the Small Molecule Repository (SMR) for ultimate distribution to the Molecular Library Screening Center Network (MLSCN) as part of the NIH Roadmap. The synthesis, purification, and characterization of this library will be presented.
 

Undergraduate Research Poster Session: Medicinal Chemistry
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Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008