CHED 1571 |
| Understanding biochemical effects exerted by various redox active molecules and elucidating their mechanism of action is important for revealing complex biochemical network in the cells, developing novel biomolecular probes and drugs. Herein, we synthesized a series of known and novel Fe(III) based transition metal complexes and investigated their biochemical effects on DNA in vitro and on cultured human cells. We showed that Fe (III)-complexes produce free radicals under reducing environment and induces DNA damage in vitro. Most interestingly, these metal-complexes induce oxidative stress, activate caspase enzymes and lead to apoptosis in human cells. |
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Research and Education in Material Science
8:00 AM-11:25 AM, Thursday, April 10, 2008 Hilton New Orleans Riverside -- HEC B, Oral
Division of Chemical Education |