CHED 469 |
| Free radical spin-traps are diamagnetic species that react with reactive free radicals to form stable paramagnetic species detectable by Electron Paramagnetic Resonance (EPR). As antioxidants, spin-traps are being investigated as possible therapeutic agents to protect against neurological diseases. The key step in the synthesis of most spin-traps is the formation of the nitrone moiety. Usually, these are one-pot, zinc-catalyzed reactions that are easily performed from commercially available starting materials and are directly characterized. Though aromatic nitrones are studied in the literature, heterocyclic aromatic nitrones have not been. We synthesized several novel heterocyclic aromatic nitrones and studied their free-radical trapping capabilities using fluorescence assays to determine the effect of heterocycles. |
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Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |