Progress toward the asymmetric generation of the quaternary stereocenter in Lyngbyatoxin A

CHED 419

David B. Ball, dball@csuchico.edu and Karl Voigtritter, kvoigtritter@mail.csuchico.edu. Department of Chemistry and Biochemistry, California State University, Chico, 400 W. First Street, Chico, CA 95929-0210
In our current studies of the total non-racemic synthesis of Lyngbyatoxin A and analogs, we are investigating the copper catalyzed asymmetric addition of organozinc reagents to α, β-unsaturated lactams to generate the quaternary stereocenter present in Lyngbyatoxin A. Results of this investigation will be presented.