Binding studies of organic dyes to DNA aptamers and B and Z-DNA

CHED 264

Michael Guericke, mike.guericke@doane.edu, Andrea E. Holmes, andrea.holmes@doane.edu, Katie Wilcox, katie.wilcox@doane.edu, and Casey L. Gustafson, casey.gustafson@doane.edu. Department of Chemistry, Doane College, 1014 Boswell, Crete, NE 68333
We developed colorimetric narcotic sensors from short DNA sequences called aptamers and long DNA polymers (PolyGC). Binding studies with organic dyes were performed with circular dichroism (CD) and UV-visible spectroscopy. Our results gave insight into the binding mechanisms well as the DNA conformation. The goal of this our work is the development of sensitive, reliable, and economical narcotic molecular color sensors for use in the law enforcement, forensics, or commercial industry.
 

Undergraduate Research Poster Session: Analytical Chemistry
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008