ANYL 140 |
| Reported here is the development of electron-transfer responsive liposome systems that release their contents upon reduction. To date, we have demonstrated that diphosphatidylethanolamine (PE) lipids possessing an electroactive N-quinone group can be formed into stable vesicles (liposomes). These quinone-PE liposomes are disrupted when the quinone functionality is reduced by 2 electrons per equivalent to cause an intramolecular cyclization/cleavage reaction of the reduced quinone. The rates of liposome opening are a function of quinone ring subsituents and composition of the liposome. These systems show great promise for reagent delivery in microanalysis devices, for they can be site-selective in their contents delivery, and rapid mixing/diffusion of the contents with their environment is achievable. A discussion of these electron-transfer responsive systems will be presented, including their synthesis and characterization, and their functionality as release agents. |
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Nanomaterials in Analytical Chemistry
8:25 AM-12:25 PM, Monday, April 7, 2008 Morial Convention Center -- Rm. 335, Oral
Division of Analytical Chemistry |