Controlled release of nitric oxide from nanoparticles through electrospun biodegradable fibers

COLL 336

Harvey A. Liu, hal041000@utdallas.edu1, Hector Osuna1, and Kenneth J. Balkus Jr., balkus@utdallas.edu2. (1) Department of Chemistry, The University of Texas at Dallas, 2601 North Floyd Road, Richardson, TX 75083, (2) Department of Chemistry and The Alan G. MacDiarmid NanoTech Institute, The University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080-3021
A great deal of medical devices depend on the biocompatibility of blood contacting surface of implants. However, all of the methods that have been created in order to improve blood compatibility have not been completely successful. One possible solution to these problems is to use hydrophobic polymer materials in conjunction with nanosized zeolitic material that are able to release and store nitric oxide (NO). In the body the endothelial cells produce NO to prevent platelet adhesion and activation and promote vasodilation of the surrounding blood vessels. The ability to locally release NO in a controlled manner could improve the performance of some medical devices, such as intra-arterial chemical sensors where arterial constriction at the implant site can impede sensor performance. Previous studies have shown the ability of incorporating NO releasing compounds within polymeric materials. In our study we attempt to incorporate these NO releasing compounds within electrospun water-degradable polymer fibers of a free-standing paper to provide a more controlled generation and release of NO to the target location.
 

Polymer-Nanoparticle Systems: Theory, Simulation, Experiments
2:00 PM-5:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Rm. 227, Oral

Division of Colloid & Surface Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008