COLL 301 |
| Nearly uniform silica particles were synthesized with different sizes (100-200 nm, hydrodynamic radius). The particles were amino-functionalized and passivated using varying ratios of 3-(trimethoxymethyl)-1-propanamine and trimethoxymethylsilane. The surface density of amino groups was quantified using UV/Vis spectroscopy after reaction with ninhydrin. The zeta potential of these particles was measured as function of the surface density of amino groups. The functionalized/passivated silica particles were dispersed in tetrahydrofuran and reacted with N6-Carbobenzoxy-L-lysine N-carboxyanhydride to yield hybrid particles with a silica core and poly(carbobenzyloxy-L-lysine) shell. Teramoto and coworkers1 showed that poly(carbobenzyloxy-L-lysine) has a coil-to-helix transition when warmed in m-cresol solutions. The existence and nature of that transition when the polymer is tethered to a spherical silica surface will be discussed. Reference List 1) Matsuoka,M.; Norisuye,T.; Teramoto,A.; Fujita,H. Solution properties of synthetic polypeptides. XV. Helix-coil transition in poly(e-carbobenzyloxy L-lysine). Biopolymers 1973, 12, 1515-1532. |
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Polymer-Nanoparticle Systems: Theory, Simulation, Experiments
9:00 AM-12:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Rm. 227, Oral
Division of Colloid & Surface Chemistry |