POLY 64 |
| The concept of amplification is inherent in chain-growth polymerization schemes as numerous propagation steps result from a single initiation event. The ability to chemically link a chain-growth mechanism to materials present at minute levels offers a novel amplification scheme for detection of nano-scale levels of material. Specifically, the photopolymerization of acrylate monomers affords an advantageous signal amplification method to detect biological-recognition events occurring in limited quantities. The fundamental criterion in achieving this polymerization-based amplification involves the synthesis of a macro-initiator. This dual-functional molecule contains initiator groups that commence the polymerization and biological moieties that recognize appropriate biological binding partners. Recent studies demonstrate the feasibility of polymerization-based amplification to generate macroscopically observable polymer from as low as ~1000 targeted molecules of biological material on a surface. |
|
Functional Nanomaterials from New Polymer Synthetic Methodologies
2:00 PM-5:50 PM, Sunday, April 6, 2008 Hilton New Orleans Riverside -- Grand Salon 3, Oral
Division of Polymer Chemistry |