DNA damage and repair kinetics in mammalian cells by reactants, intermediates and products associated with the reaction of combined chlorine and formaldehyde in drinking water

ENVR 272

Yukako Kumada, ykumada@uiuc.edu1, Susana Y. Kimura, skimura2@uiuc.edu1, Benito J. Mariņas, marinas@uiuc.edu1, Elizabeth D. Wagner, edwagner@uiuc.edu2, and Michael J. Plewa, mplewa@uiuc.edu3. (1) Department of Civil and Environmental Engineering & Center of Advanced Materials for the Purification of Water with Systems, University of Illinois at Urbana-Champaign, Urbana, IL 61801, (2) Department of Crop Sciences, University of Illinois at Urbana-Champaign, 1101 West Peabody Dr, Urbana, IL 61801, (3) Department of Crop Sciences, & Center of Advanced Materials for the Purification of Water with Systems, University of Illinois at Urbana-Champaign, Urbana, IL 61801
Many U.S. utilities may switch from free chlorine to combined chlorine for drinking water disinfection as a result of recent regulations. The formation of emerging disinfection byproducts (DBPs) associated with monochloramine will, thus, become a greater concern. DBPs targeted in this study are those that form from the reaction of monochloramine with formaldehyde. These two chemicals react quickly to form N-chloroaminomethanol, which can dehydrate to N-chloromethanimine, which decomposes to cyanide. Cyanide can react with combined chlorine to form cyanogen chloride. Many of these reactions are acid- and/or base-catalyzed and, therefore, exposure to associated reactants, intermediates and products can differ from that inferred from water samples whose pH/composition might be altered for preservation purposes. The focus of this research is to perform genomic DNA damage and repair kinetic assays in mammalian cells to investigate the genotoxicity of compounds associated with the reactions initiated by combined chlorine reacting with formaldehyde.
 

Advances in Drinking Water Disinfection and Disinfection Byproduct Management
6:00 PM-8:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- Hall A, Poster

Division of Environmental Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008