C-dots: Fluorescent core-shell silica hybrid nanoparticles for the life sciences

PMSE 177

Ulrich Wiesner, ubw1@cornell.edu, Department of Materials Science and Engineering, Cornell University, 330 Bard Hall, Ithaca, NY 14853-1501
Fluorescent hybrid nanoparticles offer enormous scientific and technological promise as labels and photon sources for a range of biotechnological and information-technology applications such as biological imaging, sensor technology, microarrays and display technology. Many applications require small, bright and photostabel nanoparticles with low particle size dispersity that can be specifically conjugated to biological macromolecules or arranged and assembled into higher-order structures and devices. As an alternative to single molecule fluorophores and quantum dots, fluorescent silica-based particles derived through the Stöber process hold particular promise since they are more biocompatible, are water soluble, silica chemistry is well established and extremely versatile, and silica is compatible with semiconductor processing. The presentation will report on programs at Cornell to develop a novel class of multifunctional silica-based fluorescent core-shell nanoparticles referred to as C-dots. Results on C-dot synthesis and characterization are discussed and various life sciences applications are demonstrated.