Multifunctional nanoparticle molecular imaging probes

ANYL 139

Jun Jack Hu, jhu@uakron.edu, Department of Chemistry, The University of Akron, 190 E. Buchtel Comm, Akron, OH 44325-3601 and Jacob J. Weingart, jjw36@uakron.edu, Department of Chemistry, University of Akron, 190 Buchtel Common, Akron, OH 44325-3601.
A new type of monolayer protected nanoparticles designed to mimic small cellular vesicles will be described. The nanoparticles contain a gold core of variable size from 5-60nm and a hydrophobic monolayer shell. The monolayer shell is about 1/3 of the density of typical alkyl thiol SAMs. Functional biomolecules for molecular recognitions and fluorescence probes can be anchored into the SAM as "mosaic" membrane for typical biological studies. The synthesis, characterization, and application of this type of nanoparticles in glyco-protein interactions will be presented.
 

Nanomaterials in Analytical Chemistry
8:25 AM-12:25 PM, Monday, April 7, 2008 Morial Convention Center -- Rm. 335, Oral

Division of Analytical Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008