Hematological effects induced by subacute inhalation of silica nanoparticles

ENVR 98

Zhen Chen, chenzhen@ihep.ac.cn1, Tiancheng Wang, puh3_jyk@bjmu.edu.cn2, Huan Meng, menghuan.bj@gmail.com1, Gengmei Xing, xinggm@ihep.ac.cn1, Hui Yuan, yuanh@ihep.ac.cn1, Chengcheng Zhang, linda_zcc@hotmail.com1, Chang Ye1, Feng Zhao, zhaof@ihep.ac.cn1, and Zhifang Chai1. (1) Lab for Bio-Environmental Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, P.O.X. 918, Yuquan Road 19B, Beijing, P.R.China, Beijing, 100049, China, (2) Third Hospital of Peking University, 49 North Garden Rd.,Haidian District, Beijing, P.R.China, Beijing, 100083, China
Inhalation of ambient particulate air pollution is associated with cardiovascular diseases, but the hematological effects caused by exposure to engineered nanoparticles are still unclear. In this study, we investigated the changes in blood rheology and oxygen-carrying ability of blood in rats after inhalation of engineering SiO2 nanoparticles for four weeks. The subacute exposure leads to significant increase in fibrinogen, blood viscosity and red cell aggregation, but does not impact the partial pressure of oxygen in arterial blood and other indexes related to oxygen-carrying ability like RBC, HCT, HGB MCV and MCHC. Hence, inhalation of silica nanoparticles can alternate the rheological properties of blood stream in vivo, but little effect on the oxygen-carrying ability of blood was indicated.
 

Environmental Behavior and Fate of Manufactured Nanomaterials
8:30 AM-12:15 PM, Tuesday, April 8, 2008 Morial Convention Center -- Rm. 235, Oral

Division of Environmental Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008