ENVR 58 |
| To maximize the validity and reproductivity of the data in nanotoxicology study, methodologically, it is necessary to guarantee the chemical form and nano-characteristic (e.g., size, nano-surface, etc.) of nanoparticle before safety evaluation of nanomaterial. In this paper, dispersion mediums used for toxicological study (in vitro) of nano-copper were systematically optimized. We found that the dispersion medium directly influences the toxicity of nanomaterial in vitro, the nano-copper appears to be more toxic in HPMC-suspended medium versus saline-suspended medium. Some factors, such as viscosity, zeta potential, pH value, inertness of suspending agent, stability of nanoparticle (e.g., chemical form, size, surface, etc.), should be considered as the criteria in suspending agent selection. It is reasonable to suppose that the data reflect the toxicological behavior of aggregation (microsized) but not the separated particles themselves (nanosized) if we only treat nanomaterial as traditional bulk substance. |
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Environmental Behavior and Fate of Manufactured Nanomaterials
8:30 AM-12:10 PM, Monday, April 7, 2008 Morial Convention Center -- Rm. 235, Oral
Division of Environmental Chemistry |