Antibody-capped mesoporous silica nanoparticles (MSN) for targeting of cancer cells

INOR 493

Igor I. Slowing, islowing@iastate.edu, Department of Chemistry, Iowa State University, 1605 Gilman Hall, Ames, IA 50011, Paul A. Kapke, Hybridoma Facility, Office of Biotechnology, Iowa State University, 1104 Molecular Biology Building, Ames, IA 50011, Steve Goodison, Interdisciplinary Center for Biotechnology Research and Department of Surgery, University of Florida, Jacksonville, FL 32209, and Victor S-Y. Lin, vsylin@iastate.edu, Department of Chemistry and Ames Laboratory, Iowa State University, 0755 Gilman Hall, Iowa State University, Ames, IA 50011.
We developed a method for using antibodies as removable caps for the encapsulation of a variety of guest molecules inside of a mesoporous silica nanoparticle (MSN) material. We demonstrated that these antibody-capped MSN exhibited binding selectivity between two different types of human breast cancer cells. It is plausible that the proteolytic enzymes present in the endo-lysosomal compartments of these cells would degrade the MSN-bound antibodies. The digestion of the antibody caps led to a novel mechanism for intracellular controlled release of drugs or imaging agents. We envision that this antibody-capped MSN material can be developed into a new cell type specific controlled release drug delivery system.
 

Nanoscience - Characterization and Applications
9:00 AM-1:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Rm. 219, Oral

Division of Inorganic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008