Biocompatibility study of mesoporous silica nanoparticles with red blood cells

INOR 494

Igor I. Slowing, islowing@iastate.edu, Department of Chemistry, Iowa State University, 1605 Gilman Hall, Ames, IA 50011 and Victor S-Y. Lin, vsylin@iastate.edu, Department of Chemistry and Ames Laboratory, Iowa State University, 0755 Gilman Hall, Iowa State University, Ames, IA 50011.
Amorphous silica particles have been shown to be toxic to red blood cells. We studied the biocompatibility of mesoporous silica nanoparticles (MSN) with rabbit red blood cells in vitro. The hemolysis assays were performed by mixing purified rabbit red blood cells with 100 μg/mL aqueous buffer suspensions of amorphous silica and MSN with and without surface derivatization. The source of the hemolytic properties of amorphous silica was also analyzed in this work, discussing the effects of different characteristics of the material on their compatibility with red blood cells. We demonstrated that MSN do not possess any hemolytic activity at these concentrations. Based on these results, we envision that the further development of MSN-based nanodevices could lead to novel drug delivery applications in vivo.
 

Nanoscience - Characterization and Applications
9:00 AM-1:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Rm. 219, Oral

Division of Inorganic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008