PMSE 178 |
| A simple ionic self-assembly process was investigated for constructing tailor-made biocompatible contrast agents for magnetic resonance imaging. In this approach, cationic materials (i.e. cationic surfaces of superparamagnetic iron oxide nanoparticles or gadolinium cations) were complexed with well-defined polyanions prepared using atom transfer radical polymerization (ATRP). The synthesized polymers (block and random copolymers) contained anionic sites (i.e. acrylic acid or methacrylic acid units) and biocompatible poly- or oligo-(ethylene glycol) segments. These well-defined polymers allowed preparation of monodisperse ultrasmall superparamagnetic iron oxide nanoparticles and defined polymer-gadolinium aggregates. Examples of in vivo applications of these novel contrast agents are discussed herein. |
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Synthesis and Self-Assembly Approaches to Polymer-Inorganic Hybrid Nanoparticles
1:30 PM-4:30 PM, Tuesday, April 8, 2008 Hilton New Orleans Riverside -- Grand Salon 24, Oral
Division of Polymeric Materials: Science & Engineering |