Asymmetric synthesis of warfarin in the undergraduate laboratory

CHED 90

David A. Vosburg, david_vosburg@hmc.edu and Terence C. Wong. Department of Chemistry, Harvey Mudd College, 301 Platt Blvd, Claremont, CA 91711
We have developed a new, microscale experiment for the undergraduate organic chemistry laboratory in which students synthesize the commercial anticoagulant warfarin in one step using a chiral organocatalyst. This experiment effectively demonstrates the concepts of asymmetric organocatalysis, transition-state stereochemistry, thin-layer and column chromatography, NMR spectroscopy, optical rotation, imines, Michael additions, and hemiacetals. This experiment is appropriate for a second-semester or advanced organic chemistry laboratory.
 

General Posters
7:30 PM-9:30 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Sci-Mix

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008