Nanomaterials for surface-enhanced Raman scattering based chemical imaging

ANYL 133

Steven R. Emory, semory@chem.wwu.edu, Daniel Finley, Matthew Holt, holtm3@cc.wwu.edu, and Candace Thompson, thompsc5@cc.wwu.edu. Department of Chemistry, Western Washington University, 516 High Street, Bellingham, WA 98225
The focus of this work is to develop new chemical imaging tools based on the unique properties offered by nanomaterials. Fluorescence-based imaging technologies are often hindered by low sensitivity and specificity to environmental conditions. In addition, high dye loading levels invariably perturb the system under study. Building on recent advances in surface-enhanced Raman scattering (SERS) and nanoparticle synthesis, we have designed a new class of magneto-optical nanostructures for SERS spectroscopy. Quantitative analyte imaging is accomplished by conjugating analyte-specific reporter ligands to SERS-active core-shell nanoparticles. By ratiometrically analyzing the SERS peaks of the reporter ligands, the concentration of target analytes (H+ or Ca2+) can be determined.
 

Nanomaterials in Analytical Chemistry
8:25 AM-12:25 PM, Monday, April 7, 2008 Morial Convention Center -- Rm. 335, Oral

Division of Analytical Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008