CHED 845 |
| Fragile X syndrome is the most common form of inherited mental retardation, being caused by the loss of the expression of the fragile X metal retardation protein (FMRP). FMRP is proposed to regulate the localization and translation of specific messenger RNAs (mRNAs). FMRP has been shown to bind with high affinity, by using its arginine-glycine-glycine (RGG) box domain, to G quadruplex forming mRNA. One of the posttranslational modifications that FMRP undergoes is the methylation of specific arginine residues located within its RGG box. In this study we use biophysical methods to evaluate to what extent this arginine methylation affects the FMRP ability to bind specifically to its G quadruplex forming proposed mRNA targets, as this posttranslational modification might provide a regulatory signal for FMRP function. |
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Undergraduate Research Poster Session: Biochemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |