Synthesis and biomedical applications of uniform-sized nanoparticles

PHYS 102

Taeghwan Hyeon, thyeon@snu.ac.kr, Jaeyun Kim, Hyon Bin Na, Kwangjin An, Taekyung Yu, Soon Gu Kwon, kwonsoongu@hotmail.com, Ji Eun Lee, Yong Il Park, and Nohyun Lee. National Creative Research Initiative Center for Oxide Nanocrystalline Materials & School of Chemical and Biological Engineering, Seoul National University, 151-744 Seoul, South Korea
We developed generalized and large-scale synthetic procedures to produce monodisperse spherical nanoparticles of many transition metals and oxides from thermolysis of metal-surfactant complexes (Angew. Chem. Int. Ed. (review) 2007, 46, 4630). Mechanism studies revealed that burst of nucleation is followed by rapid size focusing. We also synthesized various ultrathin sub-10 nm nanomaterials including ceria nanowires, goethite nanotubes, samaria nanobeams, CdSe nanoribbons and titania nanorods.

A new T1 MRI contrast agent using biocompatible MnO nanoparticles was developed for in vivo molecular and cellular imaging. Ni/NiO core/shell nanoparticles were synthesized for the selective magnetic separation of histidine-tagged proteins. We developed various kinds of multifunctional nanostructured materials based on uniform-sized nanoparticles for biomedical applications. Monodisperse nanoparticles were embedded in uniform pore-sized mesoporous silica spheres and polymer nanoparticles. We fabricated magnetic gold nanoshells consisting of gold nanoshells (for NIR photothermal therapy) that are embedded with Fe3O4 nanoparticles (for MRI contrasting agent).

 

Nanostructured Materials
8:20 AM-12:00 PM, Monday, April 7, 2008 Morial Convention Center -- Rm. 338/339, Oral

Division of Physical Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008