CHED 1323 |
| Naturally occurring flavonoid compounds have shown great biological potential in recent years, in particular the subclass of flavonoids known as aurones. Previous studies have shown that aurones exhibit anti-cancer activity as well as a variety of other pharmacological activities, including anti-inflammatory and anti-viral properties. More specifically, these studies indicate that aurones show potential in inhibiting cyclooxygenase-2 activity (COX-2), which plays an integral part in inflammation and its associated diseases, such as cancer. Furthermore, structure-activity studies have shown that halogen substituents increase anti-cancer activities of flavonoid derivatives. Therefore, the evaluation of “A” ring halogen substituted aurones is of great importance. As a result, a series of halogen substituted aurones were synthesized and characterized through NMR, IR, and elemental analysis. The synthetic methods used proved successful in the synthesis of the desired halogen substituted aurones. |
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Undergraduate Research Poster Session: Medicinal Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |