CHED 1306 |
| Samples of microcrystalline cellulose, MCC, and 10% theophylline were granulated, extruded and marumerized into wet sustained release beads. These wet beads were then exposed to several different drying methods including: freeze-drying, convection oven drying, and exposure to four different humidity conditions. The rate of theophylline release from the MCC bead systems was measured by dissolution methods using 0.01 M HCL and sodium phosphate buffer, pH 8.0 as the solvent systems. The control for this experiment was the convection oven dried beads. The results observed, based on these dissolution studies, suggest that the rate of theophylline release from each MCC dried bead system, either increases, decreases or follows the same release rate as the control sample. Which suggests that the rate of release of theophylline from each MCC sample depends on the drying method used to dry the wet bead systems. |
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Undergraduate Research Poster Session: Medicinal Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |