POLY 88 |
| Polybetaines are a class of zwitterionic polymers with a variety of biological applications including biomedical device coatings, drug delivery, and antimicrobials. Two sulfobetaine monomers, N-(3-sulfopropyl)-N-methacryloxyethyl-N,N-dimethylammonium betaine and N-(3-Sulfopropyl)-N-methacryloylamidopropyl-N,N-dimethylammonium betaine, were copolymerized with n-butyl acrylate in DMSO via conventional free radical polymerization to produce low Tg zwitterionic copolymers containing 3-13 mol% sulfobetaine. The effect of zwitterionic type (methacrylate versus methacrylamide) and concentration on solution properties were studied using solution rheology and electrospinning. Zwitterionic copolymers were electrospun from 80/20 v/v chloroform/ethanol solutions at 2-7 wt%, producing nanofibers with diameters as low as 130 nm. Scaling factors determined from plots of fiber diameter vs. concentration were consistent with increased ionic aggregation as copolymer zwitterionic content increased. |
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General Papers
2:00 PM-4:20 PM, Sunday, April 6, 2008 Hilton New Orleans Riverside -- Grand Salon 4, Oral
Division of Polymer Chemistry |