Inhibition of different nanomaterials on acetylcholinesterase

ENVR 99

Zhen-yu Wang, wang0628@ouc.edu.cn1, Jian Zhao1, Dong-mei Gao, gaodongmei2002@yahoo.com.cn1, Feng-min Li, lfm01@ouc.edu.cn1, and Baoshan Xing, bx@pssci.umass.edu2. (1) College of Environmental Science and Engineering, Ocean University of China, Songling Road 238#, Qingdao, 266100, China, (2) Department of Plant, Soil and Insect Sciences, University of Massachusetts, 80 Campus Center Way, Stockbridge Hall, Amherst, MA 01003
The denaturing effect of metal, metal oxide and carbon nanoparticles on acetylcholinesterase (AChE) was examined. At the concentration of 750 mg/l, the order of activity inhibition was carbon nanotubes > metals > metal oxides. Carbon nanotubes resulted in nearly 100% inhibition of AChE activity, with L-SWNTs showing higher inhibition than L-MWNTs. Metal particles showed different degrees of inhibition. Cu and Cu-C were similar to that of carbon nanoparticles, but Al was much weaker. Metal oxides caused slight activity reductions except Al2O3 which slightly increased the AChE activity. The inhibition on AChE activity was related to size, surface area, shape and inherent properties of different types of nanoparticles. 50% effective concentrations (EC50) were calculated. Cu and MWNTs had EC50 at 119 and 48 mg/l, respectively.
 

Environmental Behavior and Fate of Manufactured Nanomaterials
8:30 AM-12:15 PM, Tuesday, April 8, 2008 Morial Convention Center -- Rm. 235, Oral

Division of Environmental Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008