ANYL 158 |
| A quantitative method was developed for the determination of 5 prescription pharmaceutical drugs from aqueous samples by electrospray (ESI) LC/MS. The target analytes include the lipid regulator bezafibrate, the chimiotherapy drugs methotrexate and cyclofosfamide, the lipase inhibitor orlistat and the ACE (angiotensin-converting enzyme) inhibitor used in the treatment of hypertension Enalapril. This method was developed in positive and negative voltage switching mode. Using the negative and the positive voltage switching function, the analytes can be determined with one injection, without any reduction in sensitivity. Also an on-line solid phase extraction method with a loading volume of 1 ml, was developed to enrich the analytes from aqueous samples. Limits of detection in fortified matrix samples varied between 2 and 40 ng/L (after extraction). The validated method was applied to municipal wastewater, surface waters and potable waters. Four pharmaceuticals were detected in concentrations between 4 and 360 ng/L in the effluents from sewage treatment plant (STP) in Montreal and surface waters. Bezafibrate and Enalapril were the predominant pharmaceuticals observed in waste water. It appears that wastewater effluents are a point source of this kind of compounds in the environment. |
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Environmental Chemistry
8:55 AM-11:55 AM, Tuesday, April 8, 2008 Morial Convention Center -- Rm. 335, Oral
Division of Analytical Chemistry |