Synthesis of a nanostructured silica device for use in the controlled drug delivery of dopamine in the central nervous system

PHYS 432

Tessy López, tessy@xanum.uam.mx, Department of Helth, Universidad Autonoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, delegación Coyoacan, D.F, 36050, Mexico, Dulce M Esquivel, duuulceee@yahoo.com.mx, Centro de Investigaciones en química inorgánica, Universidad de Guanajuato, Unidad Noria Alta s/n, Guanajauto, 36050, Mexico, and Richard D. Gonzalez, gonzo@tulane.edu, Department of Chemical Engineering, Tulane University, New Orleans, LA 70118.
In the systemic treatment of Parkinson's disease, L-dopa has been the drug of choice. This is due to the instability of dopamine which is rapidly oxidized to the corresponding quinone in the central nervous system. In this study, we describe our efforts to stabilize dopamine by encapsulating it within a nanostructured silica device which can be directly implanted into the brain using stereotaxic surgery. The surface properties of this device are closely related to rate at which dopamine can be released. Characterization studies have been performed using standard physical methods, which include Uv-vis, BET, SEM, solid and liquid NMR, as a function of dopamine concentration within the device. In particular, the rate of drug release was found to be strongly dependent on the H2O/ETOH/TEOS ratio used in the sol-gel synthesis of the material. The behavior of dopamine and dopaminequinone adsorbed on silica can be tailored to obtain the desired rate of release. The drug release kinetics will be discussed during this presentation.
 

PHYS Poster Session - Nanostructured Materials and Nanophotonics
7:30 PM-10:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- Hall A, Poster

Division of Physical Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008