CHED 1329 |
| Branching and terminating stationary phases with chiral selectors can improve separations of enantiomers. In previous research, two branched chiral selector adsorbents terminating in (S)-Naproxen and Vancomycin were investigated. In an effort to increase yield, the reaction prior to the chiral selector attachment was optimized using Taguchi's method. In this step, triester termini are converted to carboxylic acids using dilute hydrochloric acid and heat. The effects of temperature, concentration of acid, and reaction time were studied at four levels. A L'16 array was used and the optimum conditions were approximated by the combination of factors with the largest signal to noise ratio. It was determined that greater precision could be attained through tightening a second array about the point at 50ºC, 2M HCl, and 3 hours. |
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Undergraduate Research Poster Session: Medicinal Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |