Precise mechanisms of formation and degradation of monolayer protected gold nanoparticles via electrospray ionization mass spectrometry

PHYS 9

Denis E. Bergeron, denis.bergeron@nist.gov and Jeffrey W. Hudgens, hudgens@nist.gov. Physical and Chemical Properties Division, National Institute of Standards and Technology, 100 Bureau Dr., Stop 8380, Gaithersburg, MD 20899-8380
Electrospray ionization mass spectrometry (ESI-MS) is employed to identify intermediates in the formation reaction leading to monolayer protected gold clusters. A range of reaction conditions are sampled to definitively identify which ions serve as intermediates and which are “dead-ends”. The gradual degradation of stored nanoparticle samples is also addressed, and pathways and products identified. The particles selected represent a model system for solution phase species of interest as biomedical imaging agents, cancer therapy agents, and catalysts, and it is established that ESI-MS is a powerful tool for the characterization of such nanomaterials.
 

Nanostructured Materials
8:10 AM-12:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Rm. 338/339, Oral

Division of Physical Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008