PHYS 228 |
| Recent developments in instrumentation, theoretical methodologies, and site-directed spin labeling have greatly enhanced the capabilities and applications of ESR. 1) ESR has been extended to high frequencies utilizing quasi-optical methods. High frequency ESR provides a faster "snapshot" of motional dynamics and enables a multi-frequency ESR approach to study complex molecular modes of motion. 2) 2D-ESR (analogous to 2D-NMR) frequently leads to dramatic spectral effects from molecular motions, which are particularly sensitive to their microscopic details, extracted by powerful methods of analysis. 3) Modern pulse ESR methods provide powerful means of determining large distances ranging from 10 - 80 Å. It is now possible to determine structure and function in large protein complexes in solution and in membranes. 4) ESR microscopy permits 3D micro-imaging with micron resolution. ESRM (vs. NMRM) is more sensitive per spin, its resolution is not limited by molecular diffusion, and it utilizes significantly less expensive magnet technology. |
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Physical Chemistry Awards Symposium
1:00 PM-5:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Rm. 338, Oral
Division of Physical Chemistry |